| Pair Name | Ursodiol, Bortezomib | ||
| Phytochemical Name | Ursodiol (PubChem CID: 31401 ) | ||
| Anticancer drug Name | Bortezomib (PubChem CID: 387447 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Ursodiol, Bortezomib | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Expression | EIF2AK3 | hsa9451 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A-172 | Glioblastoma | Homo sapiens (Human) | CVCL_0131 |
| LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 | |
| U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 | |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| Result | Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib | |||
| No. | Title | Href |
|---|---|---|
| 1 | Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib. ACS Chem Neurosci. 2020 May 6;11(9):1337-1346. doi: 10.1021/acschemneuro.0c00095. | Click |
